School of Public Health

Education

• Ph.D. in Toxicology at University of Minnesota, 2001
• M.S. in Environmental Risk Assessment at Chiang Mail University, 1996
• B.S. in Preventive Medicine at Tongji Medical University, 1990

Background

Assistant Research Professor, Department of Public Health, IU School of Medicine, Indianapolis, IN (2008-2011)

Postdoctoral Fellow, Cancer Research Division, Johns Hopkins School of Medicine, Baltimore, MD (2004-2008)

Postdoctoral Fellow, Department of Environmental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (2002-2004)

Research Assistant, Institute of Environmental Health, Chinese Academy of Preventive Medicine, Beijing, China (1990-1994)

Research Interests

My research focuses on oxidative stress and mitochondrial dysfunction that contribute to pathogenesis of a wide range of environmental agents affecting human health. Using genetic and pharmacological approaches and various cellular and animal models we are determining molecular mechanisms of chemicals induced oxidative damage, and dissecting the molecular components of mitochondrial genetic and bioenergetic alterations caused be environmental toxicants.

Publications

VanDuyn, N., Settivari, R., LeVora, J., Zhou, S., Unrine, J., and Nass, R. The transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration. Journal of Neurochemistry (in press).

Klaunig, J., Wang, Z., Pu, X., and Zhou, S. (2011). The role of oxidative stress and oxidative damage in carcinogenesis. Toxicology and Applied Pharmacology. 254(2):86-99.

Jiang, Y., Zhou, S., Sandusky, G., Kelly, M., and Fishel, M. (2010). Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression. Cancer Investigation. 28(9):885-895.

Sun, W., Zhou, S., Chang, S.S., McFate, T., Verma, A. , and Califano, J.A. (2009). Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydragenease kinase 2 in head and neck squamous cell carcinoma. Clinical Cancer Research. 15(2), 476-484.

McFate, T., Mohyeldin, A., Lu, H., Thakar, J., Henriques, J., Halim, N.D., Wu, H., Schell, M.J., Tsang, T.M. Teahan, O., Zhou, S., Califano, J.A., Jeoung, N.H., Harris, R.A., Verma, A. (2008). Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. Journal of Biological Chemistry. 283(33), 22700-8.

Mithani, S., Smith, I., Zhou, S., Gray, A., Koch, W., Maitra, M., and Califano, J.A. (2007). Mitochondrial resequencing arrays detect tumor-specific mutations in salivary rinses of patients with head and neck cancer. Clinical Cancer Research. 13(15), 7335-7340.

Zhou, S., Kachhap, S., Sun, W., Wu, G., Chuang, A., Poeta, L, Grumbine, L., Mithani, S., Chatterjee, Aa, Koch, W., Westra, W., Maitra, A., Glazer, C., Carducci, M., Sidransky, D., McFate, T., Verma, A., Califano, J.A. (2007). Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc. Natl. Acad. Sci. USA. 104(18), 7540-7545.

Mithani, S., Taube, J.M., Zhou, S., Smith, I.M., Koch, W., Westra, W., Califano, J.A. (2007). Mitochondrial mutations are late event in the progression of head and neck squamous cell cancer. Clinical Cancer Research, 13(5), 4331-4335.

Courses Recently Taught

P650 Environmental Chemistry

P650 Environmental Toxicology