Aurelian Bidulescu

Associate Professor
Epidemiology and Biostatistics

Epidemiology Concentration Coordinator
Epidemiology and Biostatistics

abidules@indiana.edu
(812) 856-7776
PH C102

Education
  • University of North Carolina at Chapel Hill, PhD, 2006
  • Yale University, MPH, 2002
  • Carol Davila University of Medicine, Bucharest, Romania, MD, 1994
Courses
  • SPH E659 Advanced Epidemiology Methods, since Spring 2014
  • MPH 502 Introduction to Epidemiology (Morehouse School of Medicine MPH Program - Atlanta, GA, Spring 2007 - Fall 2013
  • Lecturer for several biomedical courses (topics related to cardiovascular epidemiology, population and translational sciences, and grant writing methodology) at Morehouse School of Medicine, 2007 -2013
Background
  • Associate Professor, Indiana University Department of Epidemiology and Biostatistics, January 2014 - Present
  • Associate Professor, Morehouse School of Medicine, Atlanta, GA, July 2012 - January 2014
  • Assistant Professor, Morehouse School of Medicine, Atlanta, GA, December 2006 - June 2012
  • National Research Service Award (NRSA) through NIH/NHLBI Postdoctoral Fellow, UNC - Chapel Hill, August 2002 - June 2004
  • National Research Service Award (NRSA) through NIH/NIDDK Postdoctoral Fellow, UNC - Chapel Hill, January 2005 - December 2005
  • Ad Hoc grant reviewer (Special Emphasis Panel), National Institute of Minority Health and Health Disparities - NIMHD (NIH), since 2011
  • Health Disparities Research Award from the University of Alabama at Birmingham, 2008
  • Co-Chair, 'Biomarkers Session'; 2012 National Conference - American Heart Association (AHA) Epidemiology Council and Nutrition and Physical Activity Council, March 2012
  • Editorial Board Member, Journal of Clinical Endocrinology and Metabolism
  • Reviewer for more than 10 journals, including Circulation, American Journal of Epidemiology, PLoS Series, American Journal of Preventive Medicine
  • Reviewer, American Heart Association 'Epidemiology Council' - Spring Conference
  • Member, American College of Epidemiolgy
  • Member, American Heart Association
Research Interests

Increases in adiposity elevate the risk of cardiovascular disease (CVD) morbidity and mortality.  However, there are important sex- and race-related variations in the definitions/measurements of obesity.  Moreover, the impact of adiposity on CVD outcomes may be modified by psycho-social factors, diet, physical activity and sleep patterns, among other factors.  The relationship between increased adiposity and CVD outcomes involves interplay between 'environmental' exposures (e.g., psychosocial stress), behaviors (e.g., diet, sleep quality/quantity, physical activity, etc.) and biological determinants (e.g., ancestral genetic variation).  My team and others have documented substantial racial differences in dietary and sleep habits, adipose tissue distribution, adipokine biomarker levels, and CVD risk factor profiles associated with obesity in African Americans (AA) compared to European Americans (EA).  These striking racial differences raise questions about the generalizability of CVD risk classifications developed in EA in predicting CVD outcomes in AA, and thus elicit specific studies to assess the complex relationship between various adipose tissue depots and other measures of subclinical disease, the related biomarkers and CVD endpoints.

I have a broad background in medicine, public health and epidemiology, with specific training and expertise in several key research areas.  My clinical background training is in metabolic diseases (in Romania and France).  My US-based training is in environmental and genetic toxicology (Yale University) as well as, during my doctoral and post-doctoral training at the University of North Carolina at Chapel Hill, in cardiovascular disease and nutritional epidemiology.  I am the principal investigator of several Jackson Heart Ancillary Studies that provided, among other biomarkers, measurements for adiponectin in all the JHS participants ("Developing predictive biomarkers for left ventricular hypertrophy in obese African Americans").  In these Jackson Heart Study ancillary investigations, we put in evidence 1) an inverse relationship between serum adiponectin and left ventricular (LV) mass in normotensive and non-insulin resistant participants (suggesting that adiponectin may interact with LV mass in mediating long term CVD risk), whereas serum adiponectin was directly associated with LV mass in participants with hypertension and insulin resistance; 2) that adiponectin was inversely associated with visceral adipose tissue and directly associated with abdominal subcutaneous adipose tissue; 3) that African American (AA) without obesity or insulin resistance exhibit a positive association between global individual European Americans (EA) ancestry and adiponectin levels; that is abolishing in the setting of increased adiposity; and 4) that adiponectin levels were directly associated (instead of inversely) with incident stroke among women, even after accounting for insulin resistance and hypertension status.  This suggests that visceral adiposity is a key regulatory mechanism governing the body's metabolism and a major source of key adipokines such as adiponectin.

Selected Publications
Book Chapters

Bidulescu A., Bacanamwo M., Cardiovascular Diseases.  In Nurition in Epigenetics.  Mihai D. Niculescu, Paul Haggarty, Blackwell Publishing, Ltd., 2011.  DOI:  10. 1002/9780470959824.ch10

Bidulescu A., Alexandrescu D., Subbiah R.  Cardiotoxicology in Encyclopedia of Environmental Health - editorship of Simon Wood, PhD; Elsevier, 2011

Articles

Borak, JB, Bidulescu, A.  "Some thoughts on mulitple comparisons and their correction"  The Occupational and Environmental Medicine Report 14 (9): 27-32, 2000 - Invited Manuscript

Bidulescu, A, Chambless, L, Siega-Riz, AM, Zeisel, S, Heiss, G.  "Usual choline and betaine dietary intake and incident coronary heart disease:  the Atheroscierosis Risk in Communities (ARIC) study"  BMC Cardiovascular Disorders 2007;7:20

Bidulescu, A, Rose, KM, Wolf, SH, Rosamond, WD.  "Occupation recorded on certificates of death compared with self-report:  the ARIC Study" BMC Public Health 2007;7(1):229

Bidulescu, A, Chambless, LE, Siega-Riz, AM, Zeisel SH, Heiss G.  "Repeatability and measurement error in the assessment of choline and betaine dietary intake:  the Atheroscierosis Risk in Communities (ARIC) Study" Nutritional Journal 2009;8(1):14

Subbiah, R, Chengat, V, Clifton, JD, Rathinavel, A, Bidulescu, A, Tharmarajan, R, Selvam, GS.  "Cardiac isoform of alpha 2 macroglobulin and its reliability as a cardiac marker in HIV patients" Heart, Lung and Circulation 2010;19(2):93-5

Alonso A, Nettleton, JA, Ix, JH, de Boer, IH, Forsom, AR, Bidulescu, A, Kestenbaum, BR, Chambless, LE, Jacobs, DR.  "Dietary phosphorus, blood pressure and incidence of hypertension in the ARIC and MESA studies" Hypertension 2010;55(3):776-84

Bidulescu, A, Din-Dzietham, R, Coverson, L, Chen, R, Meng, YX, Buxbaum, SG, Gibbons, GH, Welch, VL.  "Interaction of sleep quality and psychosocial stress on obesity in African Americans: the Cardiovascular Health Epidemiology Study" BMC Public Health 2010;10:581

Liu, J, Heetderks, W, Albert, M, Hundley, G, Bidulescu, A.  "The Revolution in Risk Assessment and Disease Detection:  Implications for Populatiion Science.  The Jackson Heart Study 10th Anniversary Conference"  Ethnicity and Disease 2011;22(3) Suppl. 1:28-29

Fox, ER, Musani SK, Bidulescu, A, Nagarajarao, HS, Samdarshi, TE, Gebreab, SY, Sung, JH, Steffes, MW, Wang, TJ, Taylor, Jr., HA, Vasan, RS.  "The relation of obesity to circulating B-type Natriuretic Peptide concentrations in African Americans:  The Jackson Heart Study"  Circulation August 2011; 124(9):1021-7

Liu, J, Fox, CS. Hickson, DA, Bidulescu, A, Carr, JJ, Taylor, HA.  "Intraphepatic Fat, Abdominal Visceral Fat, and Cardiovascular Disease Risk Factors:  The Jackson Heart Study"  Arterioscierosis, Thrombosis and Vascular Biology  (ATVB) November 2011; 3(11):2715-22

Biculescu, A, Liu, J, Musani, SK, Fox, ER, Samdarshi, TE, Sarpong, DF, Vaccarino, V, Wilson, PW, Arnett, DK, Din-Dzietham, R, Taylor, HA, Gibbons, GH.  "Association of Adiponectin with Left Ventricular Mass in African Americans:  The Jackson Heart Study"  Circulation:  Heart Failure November 2011; 4(6):747-53

Hickson, DA, Liu, J, Bidulescu, A, Burchfiel, CM, Taylor, HA, Petrini, MF.  Pericardial fat is associated with impaired lung function and a restrictive lung pattern in adults:  The Jackson Heart Study.  Chest December 2011; 140(6):1567-73

Dastani, Z, Hivert, MF, Timpson, N, Perry, J, Yuan, X, Scott, RA, Hennman, P, Heid, IM, Kizer, JR, Lyytikainen, L-P, Fuchsberger, C, Tanaka, T, Morris, AP, Small, K, Isaacs, A, Beekman, M, Coassins, S, Lohman, K, Qi, L, Kanoni, S, Pankow, JS, Uh, H-W, Wu, Y, Bidulescu, A, et al.  "Fifteen Novel Loci for Adiponectin Levels and their Influence on Risk of Type 2 Diabetes and Metabolic Traits:  Results from a Multi-Ethnic Study of 45,891 Individuals"  PLoS Genetics March 2012; 8(3):1-23

Liu, J, Musani, SK, Bidulescu, A, Carr, JJ, Wilson, JG, Taylor, Fox, CS.  "Fatty Liver, Abdominal Adipose Tissue and Atherosclerotic Calcification in African Americans:  The Jackson Heart Study"  Atherosclerosis October 2012;224(2):251-5

Fox, ER, Musani, SK, Singh, P, Bidulescu, A, Samdarshi, TE, Steffes, M, Taylor, HA.  "Plasma Brain Natriuretic Peptide Concentration Predicts Longitudinal Change in Blood Pressure and Incident Hypertension in Non-Hypertensive Individuals:  The Jackson Heart Study"  Hypertension January 2013;61(1):48-54

Bidulescu, A, Liu, J, Hickson, DA, Hairston, KG, Sumner, AE, Taylor, HA, Gibbons, GH.  "Gender-Differences in the Associatioin of Abdominal Visceral Adipose Tissue with Adiponectin and Leptin in African Americans:  The Jackson Heart Study"  BMC Cardiovascular Disorders February 2012;13:9

Bidulescu, A, Liu, J, Chen, Z, Hickson, DA, Musani, S, Samdarshi, T, Fox, E, Taylor, HA, Gibbons, GH.  "Associations of adiponectin and leptin with incident coronary heart disease and ischemic stroke in African Americans:  The Jackson Heart Study"  Frontiers in Epidemiology Front.Public Health May 2013;1:16

Yaghootkar, H, Warren, L, Lawlor, D, Scott, R, Dastani, Z, Hivert, M-F, Hennman, P, Langenberg, C, Gillson, C, Buxbaum, S, Wu, Y, Lyytikainen, L-P, Ballantyne, CM, Kedenko, L, Loos, R, Raitakari, O, Allison, M, Sinaiko, A, Paulweber, B, Mohike, K, van Duijn, C, Lehtimaki, T, Bidulescu, A, Pankow, J, Meigs, J, Wareham, N, Laakso, M, Walker, M, Waterworth, D. Richards, JB, Frayling, T.  "Mendelian Randomization Studies To Understand the Role for Reduced Adiponectin Levels in Insulin Resistance or Type 2 Diabetes"  Diabetes Oct 2013:62(10):3589-98

Musani, SK, Vasan, RS, Bidulescu, A, Xanthakis, V, Sims, M, Gawalapu, RK, Samdarshi, TE, Steffes, M, Taylor, HA, Fox, ER.  "Aldosterone, C-reactive Protein, and Plasma-B Type Natriuretic Peptide Are Associated With the Development of Metabolic Syndrome and Longitudinal Changes in Metabolic Syndrome Components:  Findings From the Jackson Heart Study"  Diabetes Care Oct 2013;36(10)3084-92

Bidulescu, A., Choudhry, S, Musani SK, Buxbaum, SG, Liu, J, Rotimi CN, Wilson, JG, Taylor, HA, Gibbons, GH.  "Associations of adiponectin with individual European ancestry in African Americans:  the Jackson Heart Study"  Frontiers in Applied Genetic Epidemiology Front. Genet  Feb 2014 5:22 doi: 10.3389/fgene.2014.00022