IU Innovation Center, Room 254
- Texas Tech University, Ph.D., 2007
- Medical School of Soochow University, M.Sc , 2003
- Shanxi Medical University, M.D., 2000
- 2014 - present, graduate faculty member, Indiana University, Bloomington, IN
- 2014 - present, assistant research scientist, Department of Environmental Health, School of Public Health, Indiana University, Bloomington, IN
- 2013 - present, DABT, certified toxicologist by American Board of Toxicology
- 2012 - 2013, Research Associate, Department of Environmental Health, School of Public Health, Indiana University, Bloomington, IN
- 2010 - 2012, Postdoctoral fellow, Department of Genetics and Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA
- 2007 - 2010, Postdoctoral fellow, Center for Environmental Health, Indiana University School of Medicine, Indianapolis, IN
My research interests are dedicated to understanding of pathogenesis and mode of actions of environmental and industrial chemical-induced toxicology and carcinogenesis in rodents and their relevance to human health.
Honors and Awards
- 2015, Society of Toxicology Global Initiative Travel Award
- 2008, Best poster award, Indiana University Simon Cancer Center Annual Cancer Research Day
- 2007, Society of Toxicology graduate student travel award, 46th SOT annual meeting, Charlotte, NC
- 2007, AACR-Aflac, Incorporated Scholar-in-Training Award, 98th AACR annual meeting, Los Angeles, CA
Pu X, Wang Z, and Klaunig JE. Cryopreservation of human blood for alkaline and Fpg-modified comet assay. Toxicol Mech Methods. 2016 Mar 16:1-6. [Epub ahead of print] PubMed PMID: 26982377.
Wang Z, Neal BH, Lamb JC, and Klaunig JE. Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors. Toxicol Sci. 2015 Oct;147(2):549-61. Epub 2015 Jul 16. PubMed PMID: 26187448.
Pu X, Wang Z, Zhou S, and Klaunig JE. Protective effects of antioxidants on acrylonitrile-induced oxidative stress in female F344 rats. Environ Toxicol. 2015 Sep 2. [Epub ahead of print] PubMed PMID: 26332274.
Guan H, Lan Y, Wang Y, Wang Q, Wang C, Xu L, Chen Y, Liu W, Zhang X, Li Y, Gu Y, Wang Z*, and Xie F*. PD-L1 mediated the differentiation of tumor-infiltrating CD19+ B lymphocytes and T cells in invasive breast cancer. Oncoimmunology. 2015 Aug 12; 5(2). DOI:10.1080/2162402X.2015.1075112. (*corresponding author)
Wang Z, Zhou S, Pu X, and Klaunig JE. Acrylonitrile Induced Alterations in Mitochondrial Biogenesis and Bioenergetics in Cultured Rat Astrocytes. Int J Cancer Stud Res. 2015 June 25; 4(3):75-81
Klaunig JE, Gehen SC, Wang Z, Klein PJ, Billington R. Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis. Toxicol Sci. 2015 Jan;143(1):6-15. Epub 2014 Oct 28. PubMed PMID: 25354764.
Zhou S, Wang Z, and Klaunig JE. Caenorhabditis elegans neuron degeneration and mitochondrial suppression caused by selected environmental chemicals. Int J Biochem Mol Biol. 2013 Dec 15;4(4):191-200. eCollection 2013. PubMed PMID: 24380023; PubMed Central PMCID: PMC3867705.
Wang Z*, Wang Z*, Guo J*, Li Y, Bavarva JH, Qian C, Brahimi-Horn MC, Tan D, and Liu W. Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3053-8. Epub 2012 Feb 6. PubMed PMID: 22315407; PubMed Central PMCID: PMC3286999. (*Co-first author)
Klaunig JE, Wang Z, Pu X, and Zhou S. Oxidative stress and oxidative damage in chemical carcinogenesis. Toxicol Appl Pharmacol. 2011 Jul 15;254(2):86-99. Epub 2011 Feb 4. Review. PubMed PMID: 21296097.
Li Y, Bavarva JH, Wang Z, Guo J, Qian C, Thibodeau SN, Golemis EA, Liu W. HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression. Oncogene. 2011 Jun 9;30(23):2633-43. Epub 2011 Feb 14. PubMed PMID: 21317929; PubMed Central PMCID: PMC3164309.
Afriyie-Gyawu E*, Wang Z*, Ankrah NA, Xu L, Johnson NM, Tang L, Guan H, Huebner HJ, Jolly PE, Ellis WO, Taylor R, Brattin B, Ofori-Adjei D, Williams JH, Wang JS, Phillips TD. NovaSil clay does not affect the concentrations of vitamins A and E and nutrient minerals in serum samples from Ghanaians at high risk for aflatoxicosis. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25(7):872-84. PubMed PMID: 18569006. (*Co-first author)
Wang Z, Tang L, Sun G, Tang Y, Xie Y, Wang S, Hu X, Gao W, Cox SB, Wang JS. Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China. BMC Cancer. 2006 Dec 15;6:287. PubMed PMID: 17173682; PubMed Central PMCID: PMC1774575.
Wang Z, Li X and Klaunig JE. Mode of Action (MOA) of Triclosan Induced Mouse Liver Tumors. (2016) Toxicologist. 150: 1058. SOT 55th Annual Meeting, Mar 13-17, 2016, New Orleans, LA. (Oral presentation)
Wang Z and Klaunig JE. Mode of Action of Liver Tumors in Rodents and Relevance to Human Cancer Risk. (2015). CSOT VII. Oct 25-28, 2015, Wuhan, China. (Invited Talk)
Wang Z, Li X, Neal B, Lamb JC, Klaunig JE. The nuclear receptor constitutive androstane receptor (CAR) is essential for toxaphene-induced liver tumorigenic response in mice. (2015). Toxicologist. 144: 2338. SOT 54th Annual Meeting, Mar 22-26, 2015, San Diego, CA.
Wang Z, MacGregor JA, Gollapudi BB and Klaunig JE. (2014). Evaluation of Biomarkers of Inflammation, Oxidative Stress and Cell Proliferation in the Lungs of Mice Exposed via Inhalation to Vanadium Pentoxide. Proceeding of The 9th International Vanadium Symposium. June 29th to July 2nd, 2014 Padova, Italy.
Wang Z, Qian C, Eledet EM, Washington G, Zabaleta J, Hu JJ, Mandal D, Liu W. Exome sequencing identifies germline mutations in African American families with hereditary prostate cancer. [abstract]. In: AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr PR11. doi:10.1158/1538-7755.DISP13-PR11
Wang Z, Neal BH, Lamb JC and Klaunig JE. (2013). Mechanistic Investigation of Technical Toxaphene (TT)-Induced Mouse Liver Tumors. Toxicologist. 132: 810. (Oral presentation)