Pengcheng Xun

Assistant Scientist
Epidemiology and Biostatistics

pxun@indiana.edu
(812) 856-0772
PH C103

Education
  • Nanjing Medical University, Ph.D., 2007
  • Nantong Medical College, M.S., 2001
  • Nantong Medical College, B.S., 1998
Courses
  • SPH Q502 Imtermediate Statistics in Public Health (Guest lecturer)
  • SPH Q611 Statistics Packages in Research (Lecturer)
  • SPH E650 Nutrition Epidemiology (Guest lecturer)
  • SPH E659 Advanced Epidemiology Methods (Guest lecturer)
  • SPH E794 Doctoral Seminar (Guest lecturer)
Background
  • Assistant Scientist, Indiana University, (2013.2 - present)
  • Visiting Assistant Scientist, Indiana University (2012.10 - 2013.2)
  • Postdoctoral Research Associate, University of North Carolina at Chapel Hill (2008.8 - 2012.10)
  • Assistant Professor / Lecturer, Nantong University, Jiangsu, China (2004.5 - 2008.7)
  • Teaching Assistant, Nantong Medical College, Jiangsu, China (2001.8 - 2004.4)
Awards
  • NIH Reviewer, Early Career Reviewer program (ECR) at the Center for Scientific   Review (CSR), National Institute of Health (NIH), USA (2016)
  • Young Investigator Travelling Grant Award, American Diabetes Association, USA (2013)
  • Outstanding Reviewer, Annals of Internal Medicine, American College of Physicians, USA (2012)
  • Postdoctoral Award for Research Excellence, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (2011)
  • Distinguished Achievements on Education and Teaching, School of Public Health, Nantong University, Jiangsu, China (2007)
  • The 2nd Prize of Jiangsu Excellent Teaching Achievements, Bureau of Education, Jiangsu, China (2004)
Grants

Ongoing Research Support

NIH-RF1G056111 (He, K.): 2017-2022
Title: Trace mineral levels, the trajectory of cognitive decline and telomere attrition
Role:   Co-I

NIH-RF01AG054068 (Chen, J.) : 2016-2021
Title: Alzheimer’s disease & related dementias: geography, environments, and mechanisms
Role:   Biostatistician

NIH-R21HD086451 (Yang, J.) : 2016-2018
Title: Optimal physical and cognitive rest after sports-related concussions among youth
Role: Subcontract-PI

RWJF7273 (Yang, J.) : 2014-2016
Title: Youth sports TBI Laws: measuring public health impact on initial and recurrent concussions
Role: Biostatistics Consultant

NIH-R01ES021735 (He, K. & McClure, L.) : 2012-2017
Title: Trace element levels and risk of stroke
Role: Biostatistician

Completed Research Support (selected)

RWJF7273 (Yang, J.): 2014-2016
Title: Youth sports TBI Laws: measuring public health impact on initial and recurrent concussions
Role: Biostatistics Consultant

NNSF81072389 (Chen, F.) : 2011-2013
Title: Strategies on dimension reduction and statistical methods in genome wide association studies
Role: Co-I

ACS -RSGT-08-094-CPPB (He, K.) : 2008-2014
Title: Longitudinal study of outcomes in colon cancer survivors
Role: Biostatistician

NIH-R21NS056445 (He, K.) : 2008-2010
Title: Serum fatty acids and ischemic stroke in women
Role: Biostatistician

NIH-R01HL081572 (He, K.) : 2006-2011
Title: Trace elements and CVD risk factors among young adults
Role: Biostatistician

SRF-DPHE20050312001 (Chen, F.) : 2006-2008
Title: Statistical analysis for microarray Data
Role: Co-I

STIFP2006129 (Xun, P.) : 2006-2007
Title: Dimension reduction strategy and methods for microarray data
Role: PI

(Abbreviations: ACS: American Cancer Society; NIH: National Institute of Health; NNSF, National Natural Science Funding, China; RWJF: Robert Wood Johnson Foundation; SRF-DPHE: Specialized Research Fund for the Doctoral Program of Higher Education, China; STIFP, Science and Technology Innovation Fund, Jiangsu, China)

Research Interests

Dr. Xun's research interests lie in: 1) Nutrients (including trace elements), food groups, and dietary patterns in relation to chronic disease including CVD, diabetes, obesity, and cancer; 2) Meta-analysis and systematic review; 3) Applied statistical methods in the areas of public health, medicine, and biology (e.g. multi-level model, structural equation model, trajectory analysis, propensity score, etc.).

Selected Publications
Books

Xun, P., & He Q. Chapter 4: Multivariate Analysis. In Fang J. Handbook on Medical Statistics. Singapore: World Scientific Publishing Co Pte Ltd., 2017 (Role: Chapter Writer.)

The chapter covers the following methods:

Multivariate descriptive statistics, Hoteling’s T-squared test, MANOVA, Multivariate linear regression, Structural equation model, Logistic regression, Poisson regression, Negative binomial regression, Principal component analysis, Factor analysis, Canonical analysis, Corresponding analysis, Cluster analysis, Biclustering, Discriminant analysis, Multidimensional scaling, Generalized estimating equation, Multilevel model, High-dimensional data, and High-dimensional data visualization.

Lu, S., & Chen, F. “The 12th five-year” national programmed textbook: Medical Statistics, 3rd/2nd edition, Beijing: China Statistics Press, 2016/2007 (Role: Editor).

Chen F & Yu H. Statistical Interpretations of Some Selected Clinical Trial Cases, Beijing: The People’s Health Publishing House, 2015. ( Role: Editor).

Yu, H. The excellent textbook of Jiangsu higher education: Medical Statistics, 3rd/2nd/1st edition, Beijing: China Statistics Press, 2013/2005/2004 (Role: Editor).

Jin P & Chen F: Statistical Methods in Medical Area, 3rd edition, Shanghai: Fudan University Press, 2009 (Role: Associate editor-in-chief).

Rao K: Advances of Methods and Their Applications in Health Statistics. Beijing: People's Medical Publishing House, 2008 (Chapter Writer for "Permutation tests and their applications").

Chen F: Modern Medical Statistical Methods and STATA Application, 2nd edition, Beijing: China Statistics Press 2003(Role: Editor).

Peer-reviewed Articles in English (from n>72)

(*: first or co-first author, : corresponding or co-corresponding author)

Yang, J. *,†, Comstock R., Yi, H., Harvey H., & Xun, P. (2017). Trends of new and recurrent concussions in high school athletes before and after TBI laws. American Journal of Public Health (Accepted)

Qin, B.*, Xun, P., Zhu, N., Jacobs, D., Steffen, L., Daviglus, M., Van Horn, L., Reis, J., Loria, C., Liu, K., Sidney, S., & He, K. (2017). ­­Intake of niacin, folate, vitamin B6 and vitamin B12 through young adulthood and cognitive function in midlife. American Journal of Clinical Nutrition (Accepted) Aug 2. [Epub] doi: 10.3945/ajcn.117.157834. PMID: 28768650.

Dibaba, D.*, Xun, P., Song, Y., Rosanoff, A., Shechter M., & He, K.(2017). The effect of magnesium supplementation on blood pressure among individuals with insulin resistance, pre-diabetes, or non-communicable chronic diseases: a meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition July 19; pii: ajcn155291. doi: 10.3945/ajcn.117.155291. PMID: 28724644.

Wen, J.*, Xun, P.*, Chen, C., Quan, M., Wang, R., Liu, Y. , & He, K. (2017). Non-occupational physical activity during pregnancy and the risk of preterm birth: a meta-analysis of observational studies. Scientific Reports March. 22; 7:44842. PMID: 28327589.

Feng, H.*, Xun, P.*, Pike, K., Wills, A., Chawes, B., Bisgaard, H., Cai, W., Wan Y., & He, K. (2016) In utero exposure to 25(OH) D and risk of childhood asthma, wheeze and respiratory tract infections: a meta-analysis of birth cohort studies. Journal of Allergy and Clinical Immunology 139(5):1058-17. PMID: 27639938

Lewis, C.*, Wolf, W., Xun, P., Sandler, R., & He, K. (2016). Racial differences in dietary changes and quality of life after a colorectal cancer diagnosis: a follow-up of Study of Outcomes in Colorectal Cancer Survivors cohort. American Journal of Clinical Nutrition 103(6):1523-30. PMID: 27099251.

Quan, M.*, Xun, P.*, Chen, C., Wen, J., Wang, Y., Wang, R., Chen, P, & He, K. (2016). Walking pace and the risk of cognitive decline and dementia in elderly populations: a meta-analysis of prospective cohort studies. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 72(2):266-70. PMID: 27927757.

Chen, Y.*, Lin, L.*, Su, G., Han, M., Fan, X., Xun, P, & Xu, G. (2016). Effect of intermittent versus chronic calorie restriction on tumor incidence: a systematic review and meta-analysis of animal studies. Scientific Reports Sept. 22; 6:33739. PMID: 27653140.

Ruan, H.*, Xun, P.*, Cai, W., He, K, & Tang, Q. (2015). Habitual sleep duration and risk of childhood obesity: systematic review and dose-response meta-analysis of prospective cohort studies. Scientific Reports Nov 5; 5:16160. PMID: 26537869.

Dibaba, D.*, Xun, P., Yokota, K., White, E., & He, K. (2015). Magnesium intake and incidence of pancreatic cancer: The VITamins and Lifestyle (VITAL) study. British Journal of Cancer 113 (11):1515-21. PMID: 26554653.

Hunnicutt, J.*, He, K., & Xun, P. (2014). Dietary iron intake and body iron stores are associated with risk of coronary heart disease in a meta-analysis of prospective cohort studies. Journal of Nutrition 144(3):359-66. PMID: 24401818.

Ye, X.*, Yao, Z., Liu, L., Xun, P, & Chen, S. (2014). The non-linear threshold association between aspirin use and esophageal adenocarcinoma: results of a dose-response meta-analysis. Pharmacoepidemiology and Drug Safety 23 (3):278-84. PMID: 24436316.

Xun, P.*,†, Wu, Y., He, Q., & He, K. (2013). Fasting insulin concentrations and incidence of hypertension, stroke and coronary heart disease: a meta-analysis of prospective cohort studies. American Journal of Clinical Nutrition 98 (6): 1543-54. PMID: 24132974.

Xun, P.*, Liu, K., Cao, W., Sidney, S., Williams, D., & He, K. (2012). Fasting insulin level is positively associated with incidence of hypertension among American young adults: a 20-year follow-up study. Diabetes Care 35(7): 1532-7. PMID: 22511258.

Xun, P.*, Liu, K., Loria, C., Bujnowski, D., Shikany, J., Schreiner, P., Sidney, S., & He, K. (2012). Folate intake and incidence of hypertension among American young adults: a 20-year follow-up study. American Journal of Clinical Nutrition 95(5): 1023-30. PMID: 22491371.

Xun, P.*, & He, K. (2012). Fish consumption and incidence of diabetes: meta-analysis of data from 438,000 individuals in 12 independent prospective cohorts with an average 11-year follow-up. Diabetes Care 35(4): 935-8. PMID: 22442398. (With commentary).

Xun, P.*, Hou, N., Daviglus, M., Liu, K., Morris, J., Shikany, J., Sidney, S., Jacobs, D., & He, K. (2011). Fish oil, selenium, and mercury in relation to incidence of hypertension: a 20-year follow-up study. Journal of Internal Medicine 270 (2): 175-86. PMID: 21316044.

Xun, P.*, Liu, K., Morris, J., Daviglus, M., & He, K. (2010). Longitudinal association between toenail selenium levels and measures of subclinical atherosclerosis: the CARDIA Trace Element Study. Atherosclerosis 210(2): 662-7. PMID: 20138620.

Xun, P.*, Liu, K., Morris, J., Daviglus, M., Stevens, J., Jacobs, D., & He, K. (2010). Associations of toenail selenium levels with inflammatory biomarkers of fibrinogen, high-sensitivity C-reactive protein and interleukin-6: the CARDIA Trace Element Study. American Journal of Epidemiology 171(7): 793-800. PMID: 20219762

Xun, P.*, Chen, F., Dong, C., Qian, G., Lai, D., & Meng, J. (2007). A score method for comparison of partial genomic regions in their representatives of full-length genome of hepatitis E virus for genotyping. Intervirology 50(5): 328-35. PMID: 17687190.

Peer-reviewed Articles in Chinese (from n>52)

Xun, P.*, Qian, G.*, Zhao, Y., Yu, H., & Chen, F. (2012). Two-stage combinational dimension reduction strategy for analyzing high-dimensional data in biology field. Chinese Journal of Health Statistics 29(5): 626-9.

Xun, P.*, Qian, G., Fu, C., Yu, H., & Chen, F. (2009). Strategy of dimension reduction for microarray data driven by discriminate analysis. Chinese Journal of Health Statistics 2009; 26(2): 1-4.

Xun, P.*, Zhao, Y., Yi, H., Bai, J., Yu, H., & Chen, F. (2006). The application of permutation test in the hypothesis testing. Application of Statistics and Management 25(5): 16-21.

Xun, P.*, Zhao, Y., Bai, J., Yi, H., Yu, H., & Chen, F. (2006). Multiple comparison procedures for microarray data. Chinese Journal of Health Statistics 23(1):5-8.

Xun, P.*, Gu, H., & Chen, F. (2005). The application of a chain binomial model in the analysis of infectious disease data. Chinese Journal of Health Statistics 22(1): 49-54.

Xun, P.*, Gu, J., Gu, H., & Chen, F. (2004). The application of median-regressive and autoregressive models in predicting incidence of SARS. Chinese Journal of Health Statistics 21(4): 219-21.

Xun, P.*, & Cai, H. (2004). The skill of using Reed – Merrell method to compile an abridged life table with SAS software. Practical Preventive Medicine 11(5): 1000-3.

Xun, P.*, & Cai, H. (2003). Analysis on potential years of life lost for automobile drivers in Jiangsu from 1990 to 1999. Chinese Journal of Epidemiology 24(4): 284-7. PMID: 12820946.

Xun, P.*, Cai, H., Ge, Z., & Lu, S. (2001). An abridged truncated life table for automobile drivers from five cites in Jiangsu province during 1990s. Chinese Journal of Health Statistics 18(6): 331-3.

Xun, P.*, & Cai, H. (2001). The construction and review of current life tables. Modern Preventive Medicine 28(1): 358-61.